Human activities, the spread of pathogens, and changing climate patterns are precipitating a global mass extinction of plant biodiversity. Integrated Plant Production Systems (IPPS) encompass the use of advanced technologies to cultivate ecologically and economically important plant species, including those used for food, forestry, medicine, natural health products, and ornamental applications, particularly those at risk of extinction. This special journal volume focuses on the development and implementation of innovative, energy-efficient technologies for the conservation and propagation of plants within controlled environments. Key areas of interest include the integration of automation, machine learning, artificial intelligence, and enhanced energy efficiency in micropropagation in smart culture devices and bioreactors, vertical farming, greenhouse acclimation, and field transplantation of plants. Emphasis will be placed on research demonstrating significant progress in producing stress-resilient plants capable of enduring adverse climate conditions, that in turn, can develop into value-added safe food and medicinal products, as well as for germplasm maintenance and conservation.